INFLUENCE OF THE 2,4 DICHLOROPHENOXYACETIC ACID (TORDON®) ON WEIGHT OF THE ORGANS OF MALE ADULT WISTAR RATS

Authors

  • Jurandy Mauro Penitente-Filho Universidade Federal de Viçosa
  • Tarcízio Antônio Rego de Paula Universidade Federal de Viçosa
  • João Gabriel da Silva Neves Universidade Federal de Viçosa
  • Sérgio Luis Pinto da Matta Universidade Federal de Viçosa

DOI:

https://doi.org/10.30969/acsa.v10i1.442

Keywords:

Zootecnia, Ciencias Animais

Abstract

Thirty adult male Wistar rats were used in five groups. Two groups received oral treatment with aqueous solution of the Tordon® in different concentrations. Treatment O1: 2mL/L, (n=6); Treatment O2: 4mL/L, (n=6). Two groups received topical treatment in the cervical area: Treatment T1: 16.67mL/L (n=6), and Treatment T2: 400mL/L (n=6). A group control was used without the addition of the herbicide (n=6). Forty days after start of the experiment, the weight of the rats was assessed and they were euthanized; the internal organs (testis, liver, kidneys, spleen and intestine) were collected and their weights were assessed. There were no differences (P>0.05) in the body and organs weights among treatments. However, the proportional weight (%) of the liver in relation to body weight was higher in the O1 and O2 treatments (P<0.05) as well as the proportional weight of the kidneys in the O2 treatment. The T1 and T2 animals did not show harmful effects.

Author Biographies

  • Jurandy Mauro Penitente-Filho, Universidade Federal de Viçosa
    Departamento de Zootecnia, área de Fisiologia e Reprodução Animal
  • Tarcízio Antônio Rego de Paula, Universidade Federal de Viçosa
    Departamento de Veterinária
  • João Gabriel da Silva Neves, Universidade Federal de Viçosa
    Departamento de Veterinária
  • Sérgio Luis Pinto da Matta, Universidade Federal de Viçosa
    Departamento de Biologia Geral

References

<p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 200%;"><span style="font-size: 12.0pt; line-height: 200%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-bidi-font-family: &quot;Times New Roman&quot;; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US;" lang="EN-US">FRAN&Ccedil;A, L.R. An&aacute;lise morfofuncional da espermatog&ecirc;nese de su&iacute;nos adultos da ra&ccedil;a Piau (Morphofunctional analyses of spermatogenesis of adult pigs of Piau breed). Thesis (Master degree),<strong> </strong>Federal University of Minas Gerais. Belo Horizonte, Brazil. 1991</span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 200%;"><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 200%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;">GUERRA, M.P.; TORRES, A.C.; TEIXEIRA, J.B. Embriog&ecirc;nese Som&aacute;tica e Sementes Sint&eacute;ticas. In: TORRES, A.C.; CALDAS, L.S.; BUSO, J.A. (Ed.). Culturas de Tecidos e Transforma&ccedil;&atilde;o Gen&eacute;tica de Plantas. Bras&iacute;lia, Embrapa-CBAB. v.2. p. 533-568. 1999.</span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 200%;"><span style="font-size: 12.0pt; line-height: 200%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-fareast-font-family: &quot;Times New Roman&quot;; mso-ansi-language: EN-US; mso-fareast-language: PT-BR; mso-bidi-font-weight: bold;" lang="EN-US">GORZINSKI, S.J., KOCIBA, R.J.; CAMPBELL, R.A.; SMITH, F.A.; NOLAN, R.J.; EISENBRANDT, D.L., Acute, pharmacokinetic, and subchronic toxicological studies of 2,4-dichlorophenoxyacetic acid. </span><a href="http://www.sciencedirect.com/science/journal/02720590"><span style="font-size: 12.0pt; line-height: 200%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-fareast-font-family: &quot;Times New Roman&quot;; color: windowtext; mso-ansi-language: EN-US; mso-fareast-language: PT-BR; mso-bidi-font-weight: bold; text-decoration: none; text-underline: none;" lang="EN-US">Fund Appl Toxicol</span></a><span style="font-size: 12.0pt; line-height: 200%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-fareast-font-family: &quot;Times New Roman&quot;; mso-ansi-language: EN-US; mso-fareast-language: PT-BR; mso-bidi-font-weight: bold;" lang="EN-US">, v.</span><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 200%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;">9,</span><span style="font-size: 12.0pt; line-height: 200%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-fareast-font-family: &quot;Times New Roman&quot;; mso-ansi-language: EN-US; mso-fareast-language: PT-BR;"> <span lang="EN-US">p.423-435, 1987.</span></span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 200%;"><strong><span style="font-size: 12.0pt; line-height: 200%; mso-bidi-font-family: &quot;Times New Roman&quot;; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US;" lang="EN-US">LACHAPELLE, A.M.; RUYGROK, M.L.; TOOMER, M.; OOST, J.J.; MONNIE, M.L.; SWENSON, J.A.; COMPTON, A.A.; STEBBINS-BOAZ, B.<a name="bcor1"></a> </span></strong><span style="font-size: 12.0pt; line-height: 200%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-bidi-font-family: &quot;Times New Roman&quot;; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US;" lang="EN-US">The hormonal <a name="hit1"></a><span class="hit">herbicide,</span> 2,4-dichlorophenoxyacetic acid, inhibits <em>Xenopus</em> oocyte maturation by targeting translational and post-translational mechanisms. Reprod. Toxicol.&nbsp;v.23, p.20-31, 2007.</span></p> <p style="margin: 0cm; margin-bottom: .0001pt; text-align: justify; line-height: 200%;"><strong><span lang="EN-US">OAKES, D.J.; POLLAK, J.K. </span></strong><span lang="EN-US">Effects of a herbicide formulation, Tordon 75D<sup>&reg;</sup>, and its individual components on the oxidative functions of mitochondria. </span>Toxicology,&nbsp;v.136, p.41-52, <strong><span lang="EN-US">1999.</span></strong><span lang="EN-US"></span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 200%;"><span style="font-size: 12.0pt; line-height: 200%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-bidi-font-family: &quot;Times New Roman&quot;; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US;" lang="EN-US">OAKES, D.J.; WEBSTER, W.S.; BROWN-WOODMAN, P.D.C.; RITCHIE; H.E. Testicular changes induced by chronic exposure to the herbicide formulation, Tordon 75D<sup>&reg; </sup>(2,4-dichlorophenoxyacetic acid and picloram) in rats. Reprod. Toxicol. v.16, p.281-289, 2002.</span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 200%; mso-layout-grid-align: none; text-autospace: none;"><span style="font-size: 12.0pt; line-height: 200%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-bidi-font-family: &quot;Times New Roman&quot;; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US;" lang="EN-US">SAS Institute Inc. 2002: SAS/STAT<sup>&reg;</sup> 9.0 User&rsquo;s guide. Cary, NC: SAS Institute Inc.</span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 200%;"><strong><span style="font-size: 12.0pt; line-height: 200%; mso-bidi-font-family: &quot;Times New Roman&quot;; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US;" lang="EN-US">SAUERHOFF, M.W.; BRAUN, W.H.; BLAUAND, G.E.; GEHRING, P.J. </span></strong><span style="font-size: 12.0pt; line-height: 200%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-bidi-font-family: &quot;Times New Roman&quot;; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US;" lang="EN-US">The fate of 2,4-<span class="hit">dichlorophenoxyacetic </span>acid (2,4-D) following oral administration to man.<em> </em>Toxicology,&nbsp;v.8, p.3-11, 1977.</span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 200%;"><strong><span style="font-size: 12.0pt; mso-bidi-font-size: 10.0pt; line-height: 200%; mso-ansi-language: EN-US;" lang="EN-US">TIMCHALK, C. </span></strong><span style="font-size: 12.0pt; mso-bidi-font-size: 10.0pt; line-height: 200%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-ansi-language: EN-US; mso-bidi-font-weight: bold;" lang="EN-US">Comparative inter-species pharmacokinetics of phenoxyacetic acid herbicides and related organic acids. </span><span style="font-size: 12.0pt; mso-bidi-font-size: 10.0pt; line-height: 200%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-ansi-language: EN-US; mso-bidi-font-style: italic;" lang="EN-US">Toxicology</span><span style="font-size: 12.0pt; mso-bidi-font-size: 10.0pt; line-height: 200%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-ansi-language: EN-US;" lang="EN-US">,&nbsp;v.200, p.1-19, <strong>2004.</strong></span></p>

Published

2014-06-11

Issue

Section

Original Articles / Artigos de Pesquisa